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NEURORADIOLOGY |
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| Case 43 : | |||
5-year-old boy with jaw & facial swelling. CT was performed. What is the diagnosis? |
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reveal a destructive soft tissue enhancing mass lesion involving the base of skull, nasopharynx, the maxillary sinuses and orbital apices.
Discussion:
Burkitt lymphoma is named after Denis Parsons Burkitt, who mapped its peculiar geographic distribution across Africa. It is a high-grade B-cell neoplasm and has 2 major forms, the endemic (African) form and the nonendemic (sporadic) form. Burkitt lymphoma is a childhood tumor but it is observed in adult patients. The Epstein-Barr virus (EBV) has been implicated strongly in the African form, while the relationship is less clear in the sporadic form. EBV is associated with about 20% of sporadic cases. Rare adult cases are associated with immunodeficiency, particularly AIDS. In the African form of Burkitt lymphoma, patients most often present with swelling of the affected jaw or other facial bones, loosening of the teeth, and swelling of the lymph nodes, which are nontender and rapidly growing, in the neck or below the jaw. Abdominal presentation is slightly less common
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